DREAM TEAM brings you all the latest injury, suspension and availability news ahead of Gameweek 6 in one easily digestible dose.
Liverpool will be able to call upon on Virgil van Dijk (£4.5m) with the Dutchman having served his extended suspension in full.
It's not known whether Trent Alexander-Arnold (£5.4m) will also be involved against West Ham but the right-back was not among the Reds' Europa League squad against LASK.
As for the Hammers, Jarrod Bowen (£4.9m) will be assessed at the weekend after he skipped his side's Europa League fixture having picked up a virus.
Mason Mount (£3.3m), Sofyan Amrbat (£3.5m) and Raphael Varane (£3.5m) all returned to Manchester United this week but Erik ten Hag refused to give a clear indication of the trio's availability for this weekend's visit to Turf Moor.
Aaron Wan-Bissaka (£3m) will be sidelined for several weeks with a hamstring injury – the Red Devils' right-back appears in 7.4% of teams at the time of writing.
Ivan Perisic (£2.7m) and Rico Henry (£2.8m) are both long-term absentees for Tottenham and Brentford respectively after suffering serious ACL injuries – the Bees have already ruled out their defender for the remainder of the season.
Armando Broja (£2m) has a chance of being among Chelsea's matchday squad for the first time this campaign while Moises Caicedo (£2.4m) will be assessed on Saturday before a final decision is made.
Noni Madueke (£2.7m) and Marc Cucurella (£2.9m) have returned to training with Reece James (£4.5m) also said to be progressing well but Aston Villa's visit to Stamford Bridge this Sunday certainly comes too soon for the Blues' skipper.
Roberto De Zerbi confirmed to journalists that he would make "a lot" of changes to his team following Brighton's defeat to AEK Athens on Thursday evening.
Late decisions will be made on Lewis Dunk (£2.7m) and Evan Ferguson (£3.3m) ahead of Sunday's home game against Bournemouth – both players are among the most-selected 15 assets in their respective positions in the realm of Dream Team.
Bernardo Silva (£3.6m) will be absent for at least a week following his premature substitution against Red Star Belgrade in midweek.
In more encouraging news for Manchester City fans, Pep Guardiola told reporters Jack Grealish (£4.4m) may be able to play "some minutes".
Mikel Arteta has not yet decided whether Aaron Ramsdale (£3.6m) or David Raya (£3.5m) start in goal against Spurs.
Gabriel Martinelli (£4.2m) is a doubt for Arsenal while Thomas Partey (£2.7m) remains sidelined.
Antonee Robinson (£2.1m) has returned to Fulham training but Marco Silva revealed Adama Traore (£2.3m) has been added to his list of absentees.
Nicolas Jackson (£2.6m) and Anthony Gordon (£2.8m) are both one yellow card away from incurring a suspension.
ARSENAL
Injuries: Jurrien Timber, Thomas Partey, Gabriel Martinelli (doubt)
Suspensions: None
ASTON VILLA
Injuries: Tyrone Mings, Emi Buendia, Tim Iroegbunam, Diego Carlos, Bertrand Traore (doubt)
Suspensions: None
BOURNEMOUTH
Injuries: Alex Scott, Ryan Fredericks, Emiliano Marcondes, Tyler Adams
Suspensions: None
BRENTFORD
Injuries: Josh Dasilva, Shandon Baptiste, Rico Henry, Mikkel Damsgaard (doubt), Ben Mee (doubt), Kristoffer Ajer (doubt)
Suspensions: Ivan Toney
BRIGHTON
Injuries: Julio Enciso, Evan Ferguson (doubt), Lewis Dunk (doubt)
Suspensions: None
BURNLEY
Injuries: Michael Obafemi, Hjalmar Ekdal, Darko Churlinov
Suspensions: Lyle Foster
CHELSEA
Injuries: Reece James, Trevoh Chalobah, Armando Broja (doubt), Christopher Nkunku, Beniot Badiashile, Wesley Fofana, Marcus Bettinelli, Carney Chukwuemeka, Romeo Lavia, Noni Madueke (doubt), Moises Caicedo (doubt)
Suspensions: None
CRYSTAL PALACE
Injuries: Michael Olise, Matheus Franca, Naouirou Ahamada, Marc Guehi (doubt), James Tomkins, Jefferson Lerma
Suspensions: None
EVERTON
Injuries: Seamus Coleman, Dele Alli, Jack Harrison
Suspensions: None
FULHAM
Injuries: Sasa Lukic, Tosin Adarabioyo, Adama Traore, Antonee Robinson (doubt)
Suspensions: None
LIVERPOOL
Injuries: Thiago Alcantara, Trent Alexander-Arnold
Suspensions: None
LUTON
Injuries: Dan Potts, Jordan Clark, Gabriel Osho, Ross Barkley (doubt)
Suspensions: None
MANCHESTER CITY
Injuries: Kevin De Bruyne, John Stones, Jack Grealish (doubt), Mateo Kovacic, Bernardo Silva
Suspensions: None
MANCHESTER UNITED
Injuries: Raphael Varane (doubt), Luke Shaw, Mason Mount (doubt), Amad Diallo, Kobbie Mainoo, Tyrell Malacia, Sofyan Amrabat (doubt), Aaron Wan-Bissaka, Harry Maguire (doubt)
Suspensions: None
NEWCASTLE
Injuries: Joe Willock, Emil Krath, Joelinton
Suspensions: None
NOTTINGHAM FOREST
Injuries: Serge Aurier (doubt), Danilo, Anthony Elanga (doubt), Willy Boly (doubt)
Suspensions: None
SHEFFIELD UNITED
Injuries: Rhys Norrington-Davies, Daniel Jebbison, Rhian Brewster, John Fleck, Max Lowe, Ben Osborn, Will Osula (doubt), George Baldock, John Egan (doubt)
Suspensions: Oli McBurnie
TOTTENHAM
Injuries: Ivan Perisic, Rodrigo Bentacur, Ryan Sessegnon, Bryan Gil, Giovani Lo Celso (doubt), Alfie Whiteman
Suspensions: None
WEST HAM
Injuries: Aaron Cresswell (doubt), Jarrod Bowen (doubt)
Suspensions: None
WOLVES
Injuries: Joe Hodge (doubt), Rayan Ait-Nouri (doubt)
Suspensions: None
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